我的研究領域為分子生態與演化、魚類基因體與奈米孔定序應用。近期研究著重在微生物功能基因演化與應用、淡水魚類的親緣地理學、魚類雜交行為與基因體研究。我主要協助 (a)共儀設施管理和相關培訓課程，（b）生物安全和動物實驗相關事宜，（c）新建實驗室規劃。
我參與完成的研究項目有

1. 酵母順式和反式調節基因表現的天擇
2. 利用多體學分析鑑定微生物纖維素酶功能
3. 酵母中有氧醱酵的演化
4. 魚類視蛋白基因演化
5. 微生物酶對三萜類化合物的生物轉化
6. 魚類基因體學和種間交配行為

期刊論文

1. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Cho, Shu-Chi; Wang, Tzi-Yuan; Tsao, Che-Chia; Chen, Jou-Yi; Wu, Chien-Yu; Ting, Huei-Ju, accepted, “Production of Anti-melanogenic Glucosides via Molecular Docking-guided Biotransformation of p-hydroxyphenethyl anisate”, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. (SCIE) (IF: 3.3; SCI ranking: 46.5%,41%)
2. Wu, Chien-Yu; Wu, Jiumn-Yih; Ting, Huei-Ju; Chen, Jou-Yi; Wang, Chia-Lin; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Chun-Wei; Chang, Te-Sheng, 2026, “Anti-inflammatory activity of 3 "-hydroxyisoxsuprine, a catechol-structured product of biotransformation hydroxylation, in lipopolysaccharide-stimulated RAW 264.7 macrophage cells”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 142(3), 214-221. (SCIE)
3. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Chen, Jou-Yi; Ting, Huei-Ju, 2026, “Chromatography-guided purification and characterization of p-hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo”, PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 56(6), 984-995. (SCIE) (IF: 1.9; SCI ranking: 72.7%,82%,70.5%)
4. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Guan-Cheng; Wang, Min-Lin; Ting, Huei-Ju, 2026, “Enzymatic synthesis of a new and bioactive dihydrochalcone: 3,4-dihydroxy-2′,6′-dimethoxy dihydrochalcone”, NATURAL PRODUCT RESEARCH, 40(14), 4068-4079. (SCIE)
5. Tai JH, Yu TH, Wang FY, Terai Y, Tabata R, Huang SP, Wang TY*, Wang HY*, 2026, “Chromosome-level genome assembly of the Japanese Zacco platypus for comparative genomics”, Scientific Data, 13, 149. (SCIE) (IF: 6.9; SCI ranking: 17.6%)
6. Brandon-Mong, Guo-Jie; Lee, Tzong-Huei; Chen, Yi-Lung; Hsiao, Tsun-Hsien; Wu, Guan-Lun; Lai, Yi-Li; Weng, Chieh-Yin; Gicana, Ronnie G.; Yen, Yu-Ting; Xu, Yi-Fan; Wang, Tzi-Yuan; Chiang, Yin-Ru, 2026, “Gut microbiomics reveals host-microbe crosstalk during sexual differentiation in the shortfin eel Anguilla bicolor”, ISME COMMUNICATIONS, 6(1), ycag241. (SCIE)
7. Huang, Shih-Pin; Chen, Yi-Hsiang; Wang, Tzi-Yuan, 2025, “Museum Fish Collections and DNA Barcoding Reveal the Invasion History of the Zoonotic Yellow Grub Parasite (Clinostomum sinensis) in Taiwan's Rivers”, ZOOLOGICAL STUDIES, 64, 62. (SCIE) (IF: 1.4; SCI ranking: 38.4%)
8. Wu, Chien-Yu; Khan, Muddasir; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Li, Yi-Xuan; Liu, Chun-Wei; Wu, Jiumn-Yih; Chang, Te-Sheng, 2025, “Biotransformation: a novel approach for the production of 6-hydroxyluteolin 7-O-methylglucuronide compound with antioxidant and anti-inflammatory potential”, NATURAL PRODUCT RESEARCH, 40(18), 5653-5660. (SCIE) (IF: 1.6; SCI ranking: 63.9%,78.3%)
9. Chang, Te-Sheng; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Wu, Jiumn-Yih; Tsai, Po-Wei; Suratos, Khyle S.; Tayo, Lemmuel L.; Liu, Guan-Cheng; Ting, Huei-Ju, 2025, “In silico-guided synthesis of a new, highly soluble, and anti-melanoma flavone glucoside: Skullcapflavone II-6′-O-β-glucoside”, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 72(3), 621-637. (SCIE) (IF: 2.7; SCI ranking: 63%,54.5%)
10. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan, 2025, “Enzymatic Glycosylation of Ganoderma Terpenoid via Bacterial Glycosyltransferases and Glycoside Hydrolases”, BIOMOLECULES, 15(5), 655. (SCIE) (IF: 4.8; SCI ranking: 24.3%)
11. Wu, Chien-Yu; Wu, Jiumn-Yih; Khan, Muddasir; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Huang, Hui-Ling; Li, Yi-Xuan; Chang, Te-Sheng, 2025, “Synthesis of a novel bioactive compound by biotransformation of 4-[(2',4'-dinitrophenyl)amino]-phenol (DPAP) via predicted data mining approach (PDMA)”, BIOCATALYSIS AND BIOTRANSFORMATION, 43(3), 334-343. (SCIE)
12. Wang TY#, Wu YW#, Lu HJ#, Liao TY, Tai JH, Huang SP, Wang FY, Yu TH, Ting CT, Chaw SM*, Wang HY*, 2025, “Chromosome-level genome assembly of the loach goby Rhyacichthys aspro offers insights into Gobioidei evolution”, Molecular Ecology Resources, 25(7), e14110. (SCIE) (IF: 5.5; SCI ranking: 19%,10.7%,11.8%)
13. Wang PH, Wu TY, Chen YL, Gicana RG, Lee TH, Chen MJ, Hsiao TH, Lu MJ, Lai YL, Wang TY, Li JY, Chiang YR*, 2025, “Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere”, Proceedings of the National Academy of Sciences of the United States of America, 122(10), e2422930122.
14. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Tayo, Lemmuel L.; Suratos, Khyle S.; Tsai, Po-Wei; Wang, Tzi-Yuan; Fong, Yu-Ning; Ting, Huei-Ju, 2025, “Predictive Production of a New Highly Soluble Glucoside, Corylin-7-O-β-Glucoside with Potent Anti-inflammatory and Anti-melanoma Activities”, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 197(2), 1174-1191. (SCIE) (IF: 3.3; SCI ranking: 46.5%,41%)
15. Chang, Te-Sheng; Ding, Hsiou-Yu; Wu, Jiumn-Yih; Lee, Chuan-Che; Yang, Ziting; Liu, Yu-Chuan; Wang, Tzi-Yuan, 2025, “New methyl compounds using the predicted data mining approach (PDMA), coupled with the biotransformation of Streptomyces peucetius O-methyltransferase”, BIOCATALYSIS AND BIOTRANSFORMATION, 43(1), 84-96. (SCIE) (IF: 1.9; SCI ranking: 82%,70.5%)
16. Wu, Chien-Yu; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Chun-Wei; Wu, Jiumn-Yih; Chang, Te-Sheng, 2024, “Development of a New Isoxsuprine Hydrochloride-Based Hydroxylated Compound with Potent Antioxidant and Anti-Inflammatory Activities”, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 34(12), 2693-2701. (SCIE)
17. Chang, Te-Sheng; Ding, Hsiou-Yu; Wu, Jiumn-Yih; Lin, Han-Ying; Wang, Tzi-Yuan, 2024, “Glycosylation of 6-gingerol and unusual spontaneous deglucosylation of two novel intermediates to form 6-shogaol-4'-O-β-glucoside by bacterial glycosyltransferase”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(10), e00779-24. (SCIE) (IF: 3.7; SCI ranking: 32.1%,39.3%)
18. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Lin, Han-Ying; Wang, Tzi-Yuan, 2024, “Exploring gingerol glucosides with enhanced anti-inflammatory fl ammatory activity through a newly identified fi ed a-glucosidase (ArG) from Agrobacterium radiobacter DSM 30147”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 138(3), 218-224. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)
19. Lin JJ, Wang FY, Chung WY, Wang TY*, 2024, “The genomic evolution of visual opsin genes in amphibians”, Vision Research, 222, 108447. (SCIE) (IF: 1.4; SCI ranking: 91.1%,75.8%,76.3%)
20. Mattos FMG*, Dreyer N*, Fong CL, Wen YV, Jain D, De Vivo M, Huang YS, Mwihaki JK, Wang TY, Ho MJ, Tsai IJ, Wang J, Chan BKK, Machida RJ*, 2024, “Potential PCR amplification bias in identifying complex ecological patterns: Higher species compositional homogeneity revealed in smaller‐size coral reef zooplankton by metatranscriptomics”, Molecular Ecology Resources, 24 (3), e13911. (SCIE) (IF: 5.5; SCI ranking: 19%,10.7%,11.8%)
21. Chen, Wen-Chia; Wang, Ruei-Ci; Yu, Sheng-Kai; Chen, Jheng-Liang; Kao, Yu-Han; Wang, Tzi-Yuan; Chang, Po-Ya; Sheu, Hwo-Shuenn; Chen, Ssu-Ching; Liu, Wei-Ren; Yang, Ta-, I; Wu, Hsuan-Chen, 2023, “Self-Healable Spider Dragline Silk Materials”, ADVANCED FUNCTIONAL MATERIALS, 33(44), 2303571. (SCIE) (IF: 19; SCI ranking: 6.3%,6.1%,5.5%,7.5%,5%,7.5%)
22. Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Cai, Cheng-Zhi; Chang, Te-Sheng, 2023, “Antioxidant and anti-α-glucosidase activities of biotransformable dragon's blood via predicted data mining approach”, PROCESS BIOCHEMISTRY, 130, 166-173. (SCIE) (IF: 4; SCI ranking: 34.9%,28.2%,34%)
23. Ding, Hsiou-Yu; Wang, Tzi-Yuan; Wu, Jiumn-Yih; Zhang, Yun-Rong; Chang, Te-Sheng, 2023, “Novel Ganoderma triterpenoid saponins from the biotransformation-guided purification of a commercial Ganoderma extract”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 135(5), 402-410. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)
24. Wang, Tzi-Yuan; Goh, King-Siang; Wang, Liang-Jong; Wu, Li-Ling; Wang, Feng-Yu; Wu, Yu-Wei, 2023, “Long-Read Genome Sequencing of Abscondita cerata (Coleoptera: Lampyridae), the Endemic Firefly of Taiwan”, ZOOLOGICAL STUDIES, 62, e25. (SCIE) (IF: 1.4; SCI ranking: 38.4%)
25. Dreyer, Niklas; de Mattos, Felipe Monteiro Gomes; Jain, Dharmesh; Fong, Chia-Ling; De Vivo, Mattia; Wen, Yung-Hui Victoria; Huang, Yu-Hsin; Mwihaki, John Karichu; Lee, Hsin-Han; Tsai, Pei-Chen; Tsao, Yao-Feng; Chan, Benny Kwok Kan; Tsai, Isheng Jason; Machida, Ryuji J.; Wang, Tzi-Yuan; Wang, John, 2023, “The mitochondrial genome of Isognomon nucleus and mitogenomics of pteriomorphia (Bivalvia: Autobranchia)”, JOURNAL OF MOLLUSCAN STUDIES, 89(1), eyad003. (SCIE) (IF: 1.2; SCI ranking: 62.4%,47.5%)
26. Goh, King-Siang; Wang, Liang-Jong; Ni, Jing-Han; Wang, Tzi-Yuan, 2022, “Luminescent characteristics and mitochondrial COI barcodes of nine cohabitated Taiwanese fireflies”, PEERJ, 10, e14195. (SCIE) (IF: 2.4; SCI ranking: 52.7%)
27. Morgan, Brett; Wang, Tzi-Yuan; Chen, Yi-Zhen; Moctezuma, Victor; Burgos, Oscar; My Hanh Le; Huang, Jen-Pan, 2022, “Long-read Sequencing Data Reveals Dynamic Evolution of Mitochondrial Genome Size and the Phylogenetic Utility of Mitochondrial DNA in Hercules Beetles (Dynastes; Scarabaeidae)”, GENOME BIOLOGY AND EVOLUTION, 14(10), evac147. (SCIE) (IF: 2.8; SCI ranking: 35.3%,41.4%)
28. Huang, Shih-Pin; Wang, Tzi-Yuan; Lin, Ting-Yu; Huang, Hui-Chu, 2022, “Genetic diversity of the regionally endangered Chinese ricefish (Oryzias sinensis) in with comments on its conservation status”, ZOOTAXA, 5189(1), 283-307. (SCIE) (IF: 0.9; SCI ranking: 65%)
29. Wang, Ya-Lun; Lin, Chia-Yu; Huang, Shih-Pin; Lee, Chia-Yun; Tuanmu, Mao-Ning; Wang, Tzi-Yuan, 2022, “Chub movement is attracted by the collision sounds associated with spawning activities”, ZOOTAXA, 5189(1), 308-317. (SCIE) (IF: 0.9; SCI ranking: 65%)
30. Wu, Jiumn-Yih; Wang, Tzi-Yuan; Ding, Hsiou-Yu; Lee, Chuan-Che; Chang, Te-Sheng, 2022, “A Novel Soy Isoflavone Derivative, 3′-Hydroxyglycitin, with Potent Antioxidant and Anti-α-Glucosidase Activity”, PLANTS-BASEL, 11(17), 2202. (SCIE) (IF: 4.1; SCI ranking: 17.3%)
31. Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Hsu, Min-Hui; Chang, Te-Sheng, 2022, “A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh”, PLANTS-BASEL, 11(17), 2286. (SCIE) (IF: 4.1; SCI ranking: 17.3%)
32. Wu JY, Ding HY, Wang TY, Cai CZ, Chang TS*, 2022, “Application of biotransformation-guided purification in Chinese medicine: an example to produce butin from licorice”, Catalysts, 12(7), 718. (SCIE) (IF: 4; SCI ranking: 44.2%)
33. Ding HY, Wang TY, Wu JY, Tsai YL, Chang TS*, 2022, “Enzymatic synthesis of novel and highly soluble puerarin glucoside by Deinococcus geothermalis Amylosucrase”, Molecules, 27(13), 4074. (SCIE) (IF: 4.6; SCI ranking: 26.1%,34.3%)
34. De Vivo M, Lee HH, Huang YS, Dreyer N, Fong CL, de Mattos FMG, Jain D, Wen YHV, Mwihaki JK, Wang TY, Machida RJ, Wang J, Chan BKK, Tsai IJ*, 2022, “Utilisation of Oxford nanopore sequencing to generate six complete gastropod mitochondrial genomes as part of a biodiversity curriculum”, Scientific Reports, 12(9973), 1-11. (SCIE) (IF: 3.9; SCI ranking: 29.7%)
35. Wu JY, Ding HY, Luo SY, Wang TY, Tsai YL, Chang TS*, 2022, “Novel glycosylation by amylosucrase to produce glycoside anomers”, Biology-Basel, 11(6), 822. (SCIE) (IF: 3.5; SCI ranking: 22.7%)
36. Wang PH*, Chen YL, Wu TY, Wu YW, Wang TY, Shih CJ, Wei STS, Lai YL, Liu CX, Chiang YR*, 2022, “Omics and mechanistic insights into di-(2-ethylhexyl) phthalate degradation in the O2-fluctuating estuarine sediments”, Chemosphere, 299, 134406. (SCIE) (IF: 8.1; SCI ranking: 10.5%)
37. Goh KS, Lee CM, Wang TY*, 2022, “Species-specific flash patterns track the nocturnal behavior of sympatric Taiwanese fireflies”, Biology-Basel, 11(1), 58. (SCIE) (IF: 3.5; SCI ranking: 22.7%)
38. Wu JY, Ding HY, Wang TY, Tsai YL, Ting HJ, Chang TS*, 2021, “Improving aqueous solubility of natural antioxidant mangiferin through glycosylation by maltogenic amylase from Parageobacillus galactosidasius DSM 18751”, Antioxidants, 10(11), 1817. (SCIE) (IF: 6.6; SCI ranking: 15.5%,10%,13.6%)
39. Chiang CM, Wang TY, Wu JY, Zhang YR, Lin SY, Chang TS*, 2021, “Production of new isoflavone diglucosides from glycosylation of 8-hydroxydaidzein by Deinococcus geothermalis amylosucrase”, Fermentation, 7(4), 232.
40. Wu JY, Wang TY, Ding HY, Zhang YR, Lin SY, Chang TS*, 2021, “Enzymatic synthesis of novel vitexin glucosides”, Molecules, 26, 6274. (SCIE) (IF: 4.6; SCI ranking: 26.1%,34.3%)
41. Gómez-Luciano LB, Wu YW, Chiang CM, Chang TS, Wu JY*, Wang TY*, 2021, “Complete genome sequence of the soil-isolated Psychrobacillus sp. strain AK 1817, capable of biotransforming the ergostane triterpenoid antcin K”, Microbiology Resource Announcements, 10(40), e01242-20.
42. Wu JY, Ding HY, Wang TY, Zhang YR, Chang TS*, 2021, “Glycosylation of ganoderic acid G by Bacillus glycosyltransferases”, International Journal of Molecular Sciences, 22(18), 9744. (SCIE) (IF: 4.9; SCI ranking: 23.2%,32%)
43. Wang LJ, Wu YW, Wang TY*, 2021, “Characterization of the complete mitochondrial genome of Abscondita cerata (Olivier, 1911) (Coleoptera: Lampyridae) and its phylogenetic implications”, MITOCHONDRIAL DNA PART B-RESOURCES, 6(9), 2528-2530. (SCIE) (IF: 0.7; SCI ranking: 96.4%)
44. Chang TS*, Chiang CM, Wang TY, Tsai YL, Wu YW, Ting HJ*, Wu JY*, 2021, “One-pot bi-enzymatic cascade synthesis of novel Ganoderma triterpenoid saponins”, Catalysts, 11(5), 580. (SCIE) (IF: 4; SCI ranking: 44.2%)
45. Chang TS, Wang TY, Chiang CM, Lin YJ, Chen HL, Wu YW, Ting HJ*, Wu JY, 2021, “Biotransformation of celastrol to a novel, well-soluble, low-toxic and anti-oxidative celastrol-29-O-β-glucoside by Bacillus glycosyltransferases”, Journal of Bioscience and Bioengineering, 131(2), 176-182. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)