I am an Research Specialist at the Biodiversity Research Center, Academia Sinica (BRCAS), Taipei, Taiwan. I was a postdoctoral fellow at Genomic Research Center, Academia Sinica in 2005-2009. I obtained my PhD from the National Tsing-Hua University in 2004. I am equipped with molecular ecology and evolution, fish genomics and specialized in Nanopore sequencing. my current research topics focus on microbial application and evolution, phylogeography of freshwater fishes, fish genome evolution and interspecific mating behaviour. I have assisted BRC in (a) shared facility management and related training courses, (b) committees in AS bio-safety & BRC animal care experiments, and (c) new laboratory design and construction.
My major achievements involving research projects are

1. Natural selection on cis and trans regulation in yeasts
2. Cellulases identification by transcriptome and secretome analyses
3. Evolution of aerobic fermentation in yeasts
4. Opsin gene evolution in teleost
5. Biotransformation of triterpenoids by microbial enzymes
6. Fish genomes and interspecific mating behaviors

期刊論文

1. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Cho, Shu-Chi; Wang, Tzi-Yuan; Tsao, Che-Chia; Chen, Jou-Yi; Wu, Chien-Yu; Ting, Huei-Ju, accepted, “Production of Anti-melanogenic Glucosides via Molecular Docking-guided Biotransformation of p-hydroxyphenethyl anisate”, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. (SCIE) (IF: 3.3; SCI ranking: 46.5%,41%)
2. Wu, Chien-Yu; Wu, Jiumn-Yih; Ting, Huei-Ju; Chen, Jou-Yi; Wang, Chia-Lin; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Chun-Wei; Chang, Te-Sheng, 2026, “Anti-inflammatory activity of 3 "-hydroxyisoxsuprine, a catechol-structured product of biotransformation hydroxylation, in lipopolysaccharide-stimulated RAW 264.7 macrophage cells”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 142(3), 214-221. (SCIE)
3. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Chen, Jou-Yi; Ting, Huei-Ju, 2026, “Chromatography-guided purification and characterization of p-hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo”, PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 56(6), 984-995. (SCIE) (IF: 1.9; SCI ranking: 72.7%,82%,70.5%)
4. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Guan-Cheng; Wang, Min-Lin; Ting, Huei-Ju, 2026, “Enzymatic synthesis of a new and bioactive dihydrochalcone: 3,4-dihydroxy-2′,6′-dimethoxy dihydrochalcone”, NATURAL PRODUCT RESEARCH, 40(14), 4068-4079. (SCIE)
5. Tai JH, Yu TH, Wang FY, Terai Y, Tabata R, Huang SP, Wang TY*, Wang HY*, 2026, “Chromosome-level genome assembly of the Japanese Zacco platypus for comparative genomics”, Scientific Data, 13, 149. (SCIE) (IF: 6.9; SCI ranking: 17.6%)
6. Brandon-Mong, Guo-Jie; Lee, Tzong-Huei; Chen, Yi-Lung; Hsiao, Tsun-Hsien; Wu, Guan-Lun; Lai, Yi-Li; Weng, Chieh-Yin; Gicana, Ronnie G.; Yen, Yu-Ting; Xu, Yi-Fan; Wang, Tzi-Yuan; Chiang, Yin-Ru, 2026, “Gut microbiomics reveals host-microbe crosstalk during sexual differentiation in the shortfin eel Anguilla bicolor”, ISME COMMUNICATIONS, 6(1), ycag241. (SCIE)
7. Huang, Shih-Pin; Chen, Yi-Hsiang; Wang, Tzi-Yuan, 2025, “Museum Fish Collections and DNA Barcoding Reveal the Invasion History of the Zoonotic Yellow Grub Parasite (Clinostomum sinensis) in Taiwan's Rivers”, ZOOLOGICAL STUDIES, 64, 62. (SCIE) (IF: 1.4; SCI ranking: 38.4%)
8. Wu, Chien-Yu; Khan, Muddasir; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Li, Yi-Xuan; Liu, Chun-Wei; Wu, Jiumn-Yih; Chang, Te-Sheng, 2025, “Biotransformation: a novel approach for the production of 6-hydroxyluteolin 7-O-methylglucuronide compound with antioxidant and anti-inflammatory potential”, NATURAL PRODUCT RESEARCH, 40(18), 5653-5660. (SCIE) (IF: 1.6; SCI ranking: 63.9%,78.3%)
9. Chang, Te-Sheng; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Wu, Jiumn-Yih; Tsai, Po-Wei; Suratos, Khyle S.; Tayo, Lemmuel L.; Liu, Guan-Cheng; Ting, Huei-Ju, 2025, “In silico-guided synthesis of a new, highly soluble, and anti-melanoma flavone glucoside: Skullcapflavone II-6′-O-β-glucoside”, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 72(3), 621-637. (SCIE) (IF: 2.7; SCI ranking: 63%,54.5%)
10. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan, 2025, “Enzymatic Glycosylation of Ganoderma Terpenoid via Bacterial Glycosyltransferases and Glycoside Hydrolases”, BIOMOLECULES, 15(5), 655. (SCIE) (IF: 4.8; SCI ranking: 24.3%)
11. Wu, Chien-Yu; Wu, Jiumn-Yih; Khan, Muddasir; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Huang, Hui-Ling; Li, Yi-Xuan; Chang, Te-Sheng, 2025, “Synthesis of a novel bioactive compound by biotransformation of 4-[(2',4'-dinitrophenyl)amino]-phenol (DPAP) via predicted data mining approach (PDMA)”, BIOCATALYSIS AND BIOTRANSFORMATION, 43(3), 334-343. (SCIE)
12. Wang TY#, Wu YW#, Lu HJ#, Liao TY, Tai JH, Huang SP, Wang FY, Yu TH, Ting CT, Chaw SM*, Wang HY*, 2025, “Chromosome-level genome assembly of the loach goby Rhyacichthys aspro offers insights into Gobioidei evolution”, Molecular Ecology Resources, 25(7), e14110. (SCIE) (IF: 5.5; SCI ranking: 19%,10.7%,11.8%)
13. Wang PH, Wu TY, Chen YL, Gicana RG, Lee TH, Chen MJ, Hsiao TH, Lu MJ, Lai YL, Wang TY, Li JY, Chiang YR*, 2025, “Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere”, Proceedings of the National Academy of Sciences of the United States of America, 122(10), e2422930122.
14. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Tayo, Lemmuel L.; Suratos, Khyle S.; Tsai, Po-Wei; Wang, Tzi-Yuan; Fong, Yu-Ning; Ting, Huei-Ju, 2025, “Predictive Production of a New Highly Soluble Glucoside, Corylin-7-O-β-Glucoside with Potent Anti-inflammatory and Anti-melanoma Activities”, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 197(2), 1174-1191. (SCIE) (IF: 3.3; SCI ranking: 46.5%,41%)
15. Chang, Te-Sheng; Ding, Hsiou-Yu; Wu, Jiumn-Yih; Lee, Chuan-Che; Yang, Ziting; Liu, Yu-Chuan; Wang, Tzi-Yuan, 2025, “New methyl compounds using the predicted data mining approach (PDMA), coupled with the biotransformation of Streptomyces peucetius O-methyltransferase”, BIOCATALYSIS AND BIOTRANSFORMATION, 43(1), 84-96. (SCIE) (IF: 1.9; SCI ranking: 82%,70.5%)
16. Wu, Chien-Yu; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Liu, Chun-Wei; Wu, Jiumn-Yih; Chang, Te-Sheng, 2024, “Development of a New Isoxsuprine Hydrochloride-Based Hydroxylated Compound with Potent Antioxidant and Anti-Inflammatory Activities”, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 34(12), 2693-2701. (SCIE)
17. Chang, Te-Sheng; Ding, Hsiou-Yu; Wu, Jiumn-Yih; Lin, Han-Ying; Wang, Tzi-Yuan, 2024, “Glycosylation of 6-gingerol and unusual spontaneous deglucosylation of two novel intermediates to form 6-shogaol-4'-O-β-glucoside by bacterial glycosyltransferase”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(10), e00779-24. (SCIE) (IF: 3.7; SCI ranking: 32.1%,39.3%)
18. Chang, Te-Sheng; Wu, Jiumn-Yih; Ding, Hsiou-Yu; Lin, Han-Ying; Wang, Tzi-Yuan, 2024, “Exploring gingerol glucosides with enhanced anti-inflammatory fl ammatory activity through a newly identified fi ed a-glucosidase (ArG) from Agrobacterium radiobacter DSM 30147”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 138(3), 218-224. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)
19. Lin JJ, Wang FY, Chung WY, Wang TY*, 2024, “The genomic evolution of visual opsin genes in amphibians”, Vision Research, 222, 108447. (SCIE) (IF: 1.4; SCI ranking: 91.1%,75.8%,76.3%)
20. Mattos FMG*, Dreyer N*, Fong CL, Wen YV, Jain D, De Vivo M, Huang YS, Mwihaki JK, Wang TY, Ho MJ, Tsai IJ, Wang J, Chan BKK, Machida RJ*, 2024, “Potential PCR amplification bias in identifying complex ecological patterns: Higher species compositional homogeneity revealed in smaller‐size coral reef zooplankton by metatranscriptomics”, Molecular Ecology Resources, 24 (3), e13911. (SCIE) (IF: 5.5; SCI ranking: 19%,10.7%,11.8%)
21. Chen, Wen-Chia; Wang, Ruei-Ci; Yu, Sheng-Kai; Chen, Jheng-Liang; Kao, Yu-Han; Wang, Tzi-Yuan; Chang, Po-Ya; Sheu, Hwo-Shuenn; Chen, Ssu-Ching; Liu, Wei-Ren; Yang, Ta-, I; Wu, Hsuan-Chen, 2023, “Self-Healable Spider Dragline Silk Materials”, ADVANCED FUNCTIONAL MATERIALS, 33(44), 2303571. (SCIE) (IF: 19; SCI ranking: 6.3%,6.1%,5.5%,7.5%,5%,7.5%)
22. Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Cai, Cheng-Zhi; Chang, Te-Sheng, 2023, “Antioxidant and anti-α-glucosidase activities of biotransformable dragon's blood via predicted data mining approach”, PROCESS BIOCHEMISTRY, 130, 166-173. (SCIE) (IF: 4; SCI ranking: 34.9%,28.2%,34%)
23. Ding, Hsiou-Yu; Wang, Tzi-Yuan; Wu, Jiumn-Yih; Zhang, Yun-Rong; Chang, Te-Sheng, 2023, “Novel Ganoderma triterpenoid saponins from the biotransformation-guided purification of a commercial Ganoderma extract”, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 135(5), 402-410. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)
24. Wang, Tzi-Yuan; Goh, King-Siang; Wang, Liang-Jong; Wu, Li-Ling; Wang, Feng-Yu; Wu, Yu-Wei, 2023, “Long-Read Genome Sequencing of Abscondita cerata (Coleoptera: Lampyridae), the Endemic Firefly of Taiwan”, ZOOLOGICAL STUDIES, 62, e25. (SCIE) (IF: 1.4; SCI ranking: 38.4%)
25. Dreyer, Niklas; de Mattos, Felipe Monteiro Gomes; Jain, Dharmesh; Fong, Chia-Ling; De Vivo, Mattia; Wen, Yung-Hui Victoria; Huang, Yu-Hsin; Mwihaki, John Karichu; Lee, Hsin-Han; Tsai, Pei-Chen; Tsao, Yao-Feng; Chan, Benny Kwok Kan; Tsai, Isheng Jason; Machida, Ryuji J.; Wang, Tzi-Yuan; Wang, John, 2023, “The mitochondrial genome of Isognomon nucleus and mitogenomics of pteriomorphia (Bivalvia: Autobranchia)”, JOURNAL OF MOLLUSCAN STUDIES, 89(1), eyad003. (SCIE) (IF: 1.2; SCI ranking: 62.4%,47.5%)
26. Goh, King-Siang; Wang, Liang-Jong; Ni, Jing-Han; Wang, Tzi-Yuan, 2022, “Luminescent characteristics and mitochondrial COI barcodes of nine cohabitated Taiwanese fireflies”, PEERJ, 10, e14195. (SCIE) (IF: 2.4; SCI ranking: 52.7%)
27. Morgan, Brett; Wang, Tzi-Yuan; Chen, Yi-Zhen; Moctezuma, Victor; Burgos, Oscar; My Hanh Le; Huang, Jen-Pan, 2022, “Long-read Sequencing Data Reveals Dynamic Evolution of Mitochondrial Genome Size and the Phylogenetic Utility of Mitochondrial DNA in Hercules Beetles (Dynastes; Scarabaeidae)”, GENOME BIOLOGY AND EVOLUTION, 14(10), evac147. (SCIE) (IF: 2.8; SCI ranking: 35.3%,41.4%)
28. Huang, Shih-Pin; Wang, Tzi-Yuan; Lin, Ting-Yu; Huang, Hui-Chu, 2022, “Genetic diversity of the regionally endangered Chinese ricefish (Oryzias sinensis) in with comments on its conservation status”, ZOOTAXA, 5189(1), 283-307. (SCIE) (IF: 0.9; SCI ranking: 65%)
29. Wang, Ya-Lun; Lin, Chia-Yu; Huang, Shih-Pin; Lee, Chia-Yun; Tuanmu, Mao-Ning; Wang, Tzi-Yuan, 2022, “Chub movement is attracted by the collision sounds associated with spawning activities”, ZOOTAXA, 5189(1), 308-317. (SCIE) (IF: 0.9; SCI ranking: 65%)
30. Wu, Jiumn-Yih; Wang, Tzi-Yuan; Ding, Hsiou-Yu; Lee, Chuan-Che; Chang, Te-Sheng, 2022, “A Novel Soy Isoflavone Derivative, 3′-Hydroxyglycitin, with Potent Antioxidant and Anti-α-Glucosidase Activity”, PLANTS-BASEL, 11(17), 2202. (SCIE) (IF: 4.1; SCI ranking: 17.3%)
31. Wu, Jiumn-Yih; Ding, Hsiou-Yu; Wang, Tzi-Yuan; Hsu, Min-Hui; Chang, Te-Sheng, 2022, “A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh”, PLANTS-BASEL, 11(17), 2286. (SCIE) (IF: 4.1; SCI ranking: 17.3%)
32. Wu JY, Ding HY, Wang TY, Cai CZ, Chang TS*, 2022, “Application of biotransformation-guided purification in Chinese medicine: an example to produce butin from licorice”, Catalysts, 12(7), 718. (SCIE) (IF: 4; SCI ranking: 44.2%)
33. Ding HY, Wang TY, Wu JY, Tsai YL, Chang TS*, 2022, “Enzymatic synthesis of novel and highly soluble puerarin glucoside by Deinococcus geothermalis Amylosucrase”, Molecules, 27(13), 4074. (SCIE) (IF: 4.6; SCI ranking: 26.1%,34.3%)
34. De Vivo M, Lee HH, Huang YS, Dreyer N, Fong CL, de Mattos FMG, Jain D, Wen YHV, Mwihaki JK, Wang TY, Machida RJ, Wang J, Chan BKK, Tsai IJ*, 2022, “Utilisation of Oxford nanopore sequencing to generate six complete gastropod mitochondrial genomes as part of a biodiversity curriculum”, Scientific Reports, 12(9973), 1-11. (SCIE) (IF: 3.9; SCI ranking: 29.7%)
35. Wu JY, Ding HY, Luo SY, Wang TY, Tsai YL, Chang TS*, 2022, “Novel glycosylation by amylosucrase to produce glycoside anomers”, Biology-Basel, 11(6), 822. (SCIE) (IF: 3.5; SCI ranking: 22.7%)
36. Wang PH*, Chen YL, Wu TY, Wu YW, Wang TY, Shih CJ, Wei STS, Lai YL, Liu CX, Chiang YR*, 2022, “Omics and mechanistic insights into di-(2-ethylhexyl) phthalate degradation in the O2-fluctuating estuarine sediments”, Chemosphere, 299, 134406. (SCIE) (IF: 8.1; SCI ranking: 10.5%)
37. Goh KS, Lee CM, Wang TY*, 2022, “Species-specific flash patterns track the nocturnal behavior of sympatric Taiwanese fireflies”, Biology-Basel, 11(1), 58. (SCIE) (IF: 3.5; SCI ranking: 22.7%)
38. Wu JY, Ding HY, Wang TY, Tsai YL, Ting HJ, Chang TS*, 2021, “Improving aqueous solubility of natural antioxidant mangiferin through glycosylation by maltogenic amylase from Parageobacillus galactosidasius DSM 18751”, Antioxidants, 10(11), 1817. (SCIE) (IF: 6.6; SCI ranking: 15.5%,10%,13.6%)
39. Chiang CM, Wang TY, Wu JY, Zhang YR, Lin SY, Chang TS*, 2021, “Production of new isoflavone diglucosides from glycosylation of 8-hydroxydaidzein by Deinococcus geothermalis amylosucrase”, Fermentation, 7(4), 232.
40. Wu JY, Wang TY, Ding HY, Zhang YR, Lin SY, Chang TS*, 2021, “Enzymatic synthesis of novel vitexin glucosides”, Molecules, 26, 6274. (SCIE) (IF: 4.6; SCI ranking: 26.1%,34.3%)
41. Gómez-Luciano LB, Wu YW, Chiang CM, Chang TS, Wu JY*, Wang TY*, 2021, “Complete genome sequence of the soil-isolated Psychrobacillus sp. strain AK 1817, capable of biotransforming the ergostane triterpenoid antcin K”, Microbiology Resource Announcements, 10(40), e01242-20.
42. Wu JY, Ding HY, Wang TY, Zhang YR, Chang TS*, 2021, “Glycosylation of ganoderic acid G by Bacillus glycosyltransferases”, International Journal of Molecular Sciences, 22(18), 9744. (SCIE) (IF: 4.9; SCI ranking: 23.2%,32%)
43. Wang LJ, Wu YW, Wang TY*, 2021, “Characterization of the complete mitochondrial genome of Abscondita cerata (Olivier, 1911) (Coleoptera: Lampyridae) and its phylogenetic implications”, MITOCHONDRIAL DNA PART B-RESOURCES, 6(9), 2528-2530. (SCIE) (IF: 0.7; SCI ranking: 96.4%)
44. Chang TS*, Chiang CM, Wang TY, Tsai YL, Wu YW, Ting HJ*, Wu JY*, 2021, “One-pot bi-enzymatic cascade synthesis of novel Ganoderma triterpenoid saponins”, Catalysts, 11(5), 580. (SCIE) (IF: 4; SCI ranking: 44.2%)
45. Chang TS, Wang TY, Chiang CM, Lin YJ, Chen HL, Wu YW, Ting HJ*, Wu JY, 2021, “Biotransformation of celastrol to a novel, well-soluble, low-toxic and anti-oxidative celastrol-29-O-β-glucoside by Bacillus glycosyltransferases”, Journal of Bioscience and Bioengineering, 131(2), 176-182. (SCIE) (IF: 2.9; SCI ranking: 50.6%,52.1%)