Dr. Shu Fang

Research Fields

Evolutionary genetics

• We have reported that a regulatory mutation in desaturase 2, known to determine a pheromonal polymorphism in Drosophila melanogaster females, may be one of the many loci underlying the behavioral differences between the Zimbabwe and cosmoplitian races of the species. This mutation is strongly correlated with the mating pattern between the two races of the species which appear to be at the incipient stage of speciation.

• Genetic analysis of speciation
• Molecular evolution

• Genetic dissection of premating isolation in Drosophila (NSC grant)

1. Langley, C. H., K. Stevens, C. Cardeno, Y. C. G. Lee, D. R. Schrider, J. E. Pool, S. A. Langley, C. Suarez, R. Detig-Corbett, B. Kolaczkowski, S. Fang, P. M. Nista, A. K. Holloway, A. D. Kern, C. N. Dewey, Y. S. Song, M. W. Hahn, and D. J. Begun, 2012, “Genomic variation in natural populations of Drosophila melanogaster”, Genetics, 192, 533-598. (SCI) (IF: 4.007; SCI ranking: 22.8%)
2. Fang, S.1*, R. Yukilevich1*, Y. Chen, D. A. Turissini, K. Zheng, I. A. Boussy, and C.-I Wu, 2012, “Incompatibility and competitive exclusion of genomic segments between sibling Drosophila species”, PLoS Genetics, 8, e1002795 (1*: Co-first and co-corresponding authors). (SCI) (IF: 8.694; SCI ranking: 7%)
3. Cheng, Y.-J.1, S. Fang1, S.-C. Tsaur, Y.-L. Chen, H.-W. Fu, N. H. Patel, and C.-T. Ting, 2012, “Reduction of germ cells in the Odysseus null mutant causes male fertility defect in Drosophila”, Genes & Genetic Systems, 87: 273-276 (1: Co-first authors). (SCI) (IF: 0.952; SCI ranking: 88.3%,85.4%)
4. Fang S.1, C.-T. Ting1, C.-R. Lee, K.-H. Chu, C.-C. Wang, and S.-C. Tsaur, 2009, “Molecular evolution and functional diversification of fatty acid desaturases after recurrent gene duplication in Drosophila.”, Molecular Biology and Evolution, 26, 1546-1557 (1: Co-first authors). (SCI) (IF: 5.55; SCI ranking: 14.8%,8.9%,12.7%)
5. J. A. Shapiro , W. Huang, C. Zhang, M. J. Hubisz, J. Lu, D. A. Turissini, S. Fang, H.-Y. Wang, R. R. Hudson, R. Nielsen, Z. Chen and C.-I Wu（2007）. Adaptive genic evolution in the Drosophila genomes. P Natl Acad Sci USA, 104, pp.2271-2276. (SCI, Impact Factor:9.643; Ranking:5.9%)
6. Greenberg, J., Moran, J. R., Fang, S. and Wu, C.-I (2006) Adaptive loss of an old duplicated gene during incipient speciation. Mol. Biol. Evol. 23, 401-410. (SCI, Impact Factor:6.726; Ranking:11.8%)
7. Alipaz, J. A., S. Fang, N. Osada and C.-I Wu (2005) Evolution of sexual isolation during secondary contact: genotypic versus phenotypic changes in laboratory populations. Am. Nat. 165, 420-428.
8. Kohn, M. H., S. Fang, and C.-I Wu. (2004). Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes. Mol. Biol. Evol. 21:374-383.
9. Fang, S., A. Takahashi, and C.-I Wu. (2002). A mutation in the promoter of desaturase 2 is correlated with sexual isolation between Drosophila behavioral races. Genetics 162:781-784.
10. Hsu, L. T., S. Fang, M. S. Rau, K. T. Shao, K. Y. Chen, and C. A. Chen. (2001). Nucleotide polymorphism and molecular population genetics: example from the population genetics of hardwick wrass, Thalassoma hardwicke, in the South China Sea. Chinese Bioscience 44:43-65. (in Chinese)